GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs688034 | 1 | rs688034 | chr22:26689635 | CRYBB1 | chr22:26995362-27013991:- | -0.48 | -4.76 | 4.51E-6 | Coronary heart disease |
| UCEC | cis | rs10461617 | 1 | rs6885541 | chr5:56110857 | C5orf35 | chr5:56205103-56213010:+ | 0.55 | 5.94 | 1.86E-8 | Type 2 diabetes |
| UCEC | cis | rs1577917 | 1 | rs6914463 | chr6:86653415 | SNHG5 | chr6:86386726-86388451:- | -0.46 | -5.98 | 1.51E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs9473555 | 1 | rs6923124 | chr6:49419864 | MUT | chr6:49398994-49431031:- | 0.37 | 6.28 | 3.45E-9 | Folate pathway vitamin levels |
| UCEC | cis | rs1577917 | 1 | rs6923148 | chr6:86767786 | SNHG5 | chr6:86386726-86388451:- | 0.45 | 5.92 | 2.08E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs6933377 | chr6:86705255 | SNHG5 | chr6:86386726-86388451:- | 0.35 | 4.63 | 7.91E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs6936048 | chr6:86702608 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.87 | 2.76E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs568617 | 1 | rs693824 | chr11:65654783 | CTSW | chr11:65647284-65651212:+ | -0.5 | -8.35 | 3.96E-14 | Crohn's disease |
| UCEC | cis | rs1577917 | 1 | rs6940458 | chr6:86644992 | SNHG5 | chr6:86386726-86388451:- | -0.45 | -5.38 | 2.75E-7 | Response to antipsychotic treatment |
| UCEC | cis | rs568617 | 1 | rs694994 | chr11:65653309 | CTSW | chr11:65647284-65651212:+ | -0.5 | -8.14 | 1.29E-13 | Crohn's disease |
| UCEC | cis | rs7017914 | 1 | rs7007450 | chr8:71640269 | XKR9 | chr8:71581600-71648176:+ | 0.76 | 10.28 | 3.75E-19 | Bone mineral density |
| UCEC | cis | rs7017914 | 1 | rs7017914 | chr8:71591203 | XKR9 | chr8:71581600-71648176:+ | 0.77 | 10.39 | 1.91E-19 | Bone mineral density |
| UCEC | cis | rs703842 | 1 | rs703842 | chr12:58162739 | TSFM | chr12:58176536-58191367:+ | 0.39 | 4.51 | 1.27E-5 | Multiple sclerosis |
| UCEC | cis | rs7072216 | 1 | rs7072216 | chr10:100156853 | PYROXD2 | chr10:100143323-100174978:- | 0.57 | 7.92 | 4.62E-13 | Metabolite levels |
| UCEC | cis | rs71327718 | 1 | rs71327718 | chr3:125592857 | LOC100125556 | chr3:125635444-125648865:+ | 0.69 | 4.7 | 5.85E-6 | Metabolite levels (HVA/5-HIAA ratio) |